The Global Cities Hub highlights how cities are addressing pressing urban health challenges in a rapidly changing world. This initiative focuses on the impacts of climate change, urbanization, and social inequality on public health, emphasizing the need for integrated, cross-sectoral policies. Cities are at the frontline of protecting health and well-being and must innovate to strengthen resilience, especially among vulnerable populations. The Global Cities Hub fosters dialogue between local authorities, international organizations, and other stakeholders to advance urban health solutions globally. It calls for stronger multilevel governance and partnerships to ensure healthy, inclusive, and sustainable urban environments for future generations.