This case study profiles the efforts of the United States National Oceanic and Atmospheric Administration (NOAA) and other partners to enhance the region’s preparedness and response capabilities, mitigating the health threats of climate change through heat-health early warning (HHEW) systems in the Sahel. An initial pilot, launched in Senegal in 2023, was led by the National Agency of Civil Aviation and Meteorology (ANACIM) and the Directorate General of Public Health (DGSP) at the Ministry of Health and Social Action (MSAS).