This publication provides essential guidance for pharmacy professionals responding to rising temperatures and heat waves. It highlights symptoms of heat-related illness—such as heat exhaustion and heat stroke—and identifies high-risk groups including older adults, infants, pregnant individuals, athletes, people with chronic conditions, and those taking medications that affect thermoregulation. The resource explains how certain drugs may impair the body’s ability to cope with heat, leading to increased vulnerability. Pharmacists and technicians are advised to counsel patients on heat safety, monitor for symptoms, assess medication risks, and recommend behavioral adjustments such as hydration, avoiding exertion during peak heat, and staying in cool environments. The fact sheet reinforces the role of pharmacists as accessible health professionals who can contribute to community resilience through prevention and early intervention during extreme heat events. This document supports climate-responsive care in pharmacy settings and encourages heat-health literacy.