Existing assessments of the thermal-related impact of the environment on humans are often limited by the use of data that are not representative of the population exposure and/or not consider a human centred approach. Here, we combine high resolution regional retrospective analysis (reanalysis), population data and human energy balance modelling, in order to produce a human thermal bioclimate dataset capable of addressing the above limitations. The dataset consists of hourly, population-weighted values of an advanced human-biometeorological index, namely the modified physiologically equivalent temperature (mPET), at fine-scale administrative level and for 10 different population groups. It also includes the main environmental drivers of mPET at the same spatiotemporal resolution, covering the period from 1991 to 2020. The study area is Greece, but the provided code allows for the ease replication of the dataset in countries included in the domains of the climate reanalysis and population data, which focus over Europe. Thus, the presented data and code can be exploited for human-biometeorological and environmental epidemiological studies in the European continent.