This document, Karachi Heatwave Management Plan, outlines what should happen before, during and after periods of extreme heat in Karachi. It sets out strategies that government and non-government agencies will adopt to prevent heat-related illnesses and deaths in Karachi and capacitate the public, particularly the most vulnerable residents, to take protective action. The Plan describes actions of implementation partners to ensure (1) information on weather conditions and heat health is timely and specific, (2) organizations have the capacity to respond according to their roles, and (3) strategies and actions enabling increase in effectiveness over time. In June 2015 Karachi City experienced a severe heatwave that caused over 1,200 deaths and over 50,000 cases of heat illness. The heatwave caught all levels of government and first responders off-guard, highlighting the need for inter-agency coordination, clarity in roles, and a well-publicized trigger to activate a planned response. To address this need and to prevent health impacts from future heatwaves as climate change intensifies, the Commissioner Office Karachi requested support from the Climate and Development Knowledge Network (CDKN) to develop a heatwave management plan. Karachi’s first Heatwave Management Plan is the result of a technical assistance project delivered by national and international experts between October 2016 and May 2017, working closely with the Commissioner Office and other stakeholders. The Plan will be subject to an annual performance review and updated versions will be available to implementation partners accordingly.