The Multi-City Multi-Country (MCC) network is an international collaboration of research teams working on a program aiming to produce epidemiological evidence on associations between weather and health. Interest on this topic has grown in the last few years among both researchers and the general public, due to recent events of extreme weather and alarming climate change scenarios, both linked with increased health risks.The research program benefits from the use of the largest dataset ever assembled for this purpose, including information from hundreds of locations within several countries. This allows standardized analyses on local data to address specific research questions on global weather-health associations, following a formalized yet flexible method of collaboration. The MCC network has developed during the years, through correspondence between the participants and additional meetings held at other scientific conferences.