This study investigates the heat-related impacts of climate change on public health in Cyprus. Most of the health problems in Cyprus and in the Mediterranean generally, are related mainly to the warming already occurred as well as to extreme weather events such as heatwaves. In addition projections indicate that warming and extreme events will increase in future posing serious threats on human health. For the investigation of the relationship bretween hot weather condition and mortality in Cyprus, a statistical model was constructed showing linear increase of mortality with increasing temperature. Humidex is also calculated, using outputs from several regional climate models. The analysis revealed a significant increase in the Humidex in future period mainly during summer months.